Welcome

Welcome to our online home. We work on the genetics of immune-mediated and seizure-related diseases at Yale School of Medicine and the Broad Institute of MIT and Harvard. Our main focus is on finding the mechanisms underlying these diseases and developing ways to provide the right drug to the right patient. You can find more information about our projects, our publications, and our software. We occasionally tweet.

What we do

Over the last few years genetic studies have found hundreds of regions of the human genome which harbor disease risk alleles. These alleles are common in the population, perturb gene regulation in a cell type-specific manner and generally contribute a modest amount of risk to carriers. We continue to develop new approaches to understand what these perturbed mechanisms are and what the effect is on cell function, so we can uncover how disease develops. Our long-term goal is to provide new targets for therapy this way, and to predict which patients will benefit from each available therapy.